Oxidative stress in obesity and metabolic syndrome in children and adolescents.

نویسندگان

  • Maria Felicia Faienza
  • Ruggiero Francavilla
  • Rocco Goffredo
  • Annamaria Ventura
  • Flaviana Marzano
  • Gianvito Panzarino
  • Grazia Marinelli
  • Luciano Cavallo
  • Giovanna Di Bitonto
چکیده

BACKGROUND/AIMS The aim of this study was to investigate the alterations in the oxidant/antioxidant status in obese children with and without metabolic syndrome (MetS). METHODS We recruited 25 Caucasian obese children with MetS, 30 Caucasian children with simple obesity and a control group of 30 Caucasian children. We performed diacron-reactive oxygen metabolites (d-ROMs) test and biological antioxidant potential (BAP) test in order to evaluate the oxidant-antioxidant status in recruited patients. RESULTS d-ROM level was significantly higher in obese children with and without MetS (p = 0.005). The total antioxidant capacity (BAP level) was reduced in MetS and noMetS children compared to controls (p = 0.009). The subjects without MetS had higher d-ROMs test and lower BAP/d-ROMs ratio than subjects with MetS (although not significant). The ratio BAP/d-ROMs was higher in controls than noMetS and MetS children (p < 0.0001). d-ROM level was higher in prepubertal subjects with MetS than pubertal ones (p = 0.03). A direct correlation was found between d-ROM levels and BMI SDS (p = 0.0005), while an inverse correlation was found between BAP and BMI SDS (p = 0.004) and BAP/d-ROMs and BMI SDS (p = 0.0001). CONCLUSIONS This result confirms that fat accumulation plays a key role in the pathogenesis of systemic oxidative stress already during pediatric age.

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عنوان ژورنال:
  • Hormone research in paediatrics

دوره 78 3  شماره 

صفحات  -

تاریخ انتشار 2012